Bosphorus Med J. 2023; 10(2): 78-82 | DOI: 10.14744/bmj.2022.99815

COVID-19 Pandemisi Sýrasýnda Hastalarda Artan Nöbet Riski: Tek Ýlaç Rejimi Daha Ýyi mi?

Ümmü Serpil Sarý, Figen Tokuçoðlu
Balýkesir Üniversitesi Týp Fakültesi Nöroloji Anabilim Dalý, Balýkesir, Türkiye

GÝRÝÞ ve AMAÇ: Artan stres, anksiyete, depresyon, çoklu antiepileptik ilaç kullanýmý ve koronavirüs hastalýðý (COVID-19), epilepsili denekler arasýnda artan nöbet oraný ile iliþkiliydi. Bu nedenle bu çalýþmada, COVID-19 pandemisi sýrasýnda epilepsili olgularda sosyal izolasyonun nöbet sýklýðýný artýrýp artýrmadýðýnýn araþtýrýlmasý ve altta yatan olasý nedenin tanýmlanmasý amaçlandý.
YÖNTEM ve GEREÇLER: Bu retrospektif, kesitsel çalýþmaya epilepsi tanýlý 103 olgu dahil edildi. Altta yatan anksiyete ve depresyonu belirlemek için hastane anksiyete ve depresyon ölçekleri kullanýldý.
BULGULAR: Bu çalýþmada 103 olgunun 58'i kadýndý ve bunlarýn %51,4'ü fokal epilepsi hastasýydý. Fokal ve jeneralize epilepsi gruplarýndaki denekler yaþ, cinsiyet, eþlik eden hastalýk varlýðý ile anksiyete ve depresyon puanlarý açýsýndan benzerdi. Ancak nöbet oranlarýnda artýþ ile baþvuran deneklerin anksiyete skorlarý daha yüksek ve yandaþ hastalýklarý daha fazlaydý. Ek olarak çoðunluðu çoklu antiepileptik ilaçlar kullanýyordu.
TARTIÞMA ve SONUÇ: Çoklu antiepileptik ilaç kullanan epilepsili olgularda, eþlik eden hastalýklarý ve anksiyete skorlarý yüksek olanlarda nöbet hýzýnda artýþ riski daha fazlaydý.

Anahtar Kelimeler: Anksiyete, COVID-19 koronavirüs hastalýðý, depresyon, epilepsi, polifarmasi, nöbet oraný, sosyal izolasyon, stres.

---

Increased Seizure Risk Among the Patients During the COVID-19 Pandemic: Is a Single-Drug Regime Better?

Ümmü Serpil Sarý, Figen Tokuçoðlu
Department of Neurology, Balikesir University Faculty of Medicine, Balikesir, Türkiye

INTRODUCTION: Increased stress, anxiety, depression, multi-anti-epileptic drug usage, and COVID-19 infection were all being related with an increased rate of seizures among subjects with epilepsy. Thus, in this study, we aimed to investigate whether social isolation increased the frequency of seizures among the cases with epilepsy during the COVID-19 pandemic and to define the possible underlying cause of it.
METHODS: In this retrospective, cross-sectional study, 103 subjects with a diagnosis of epilepsy were included in the study. Hospital anxiety and depression scales were used to determine the underlying anxiety and depression.
RESULTS: In this study, 58 out of 103 subjects were female and 51.4% of them had focal epilepsy. Subjects in focal and generalized epilepsy groups were similar based on age, gender, the presence of comorbid diseases, and anxiety and depression scores. However, the subjects presenting with increased rates of seizure had higher anxiety scores and more comorbid diseases, and in addition, the majority of them were on multi-anti-epileptic medications.
DISCUSSION AND CONCLUSION: The risk of having an increased seizure rate was greater among the subjects with epilepsy who were on multi-anti-epileptic drugs and who had comorbid diseases and increased anxiety scores.

Keywords: Anxiety, COVID-19 infection, depression, epilepsy, polypharmacy, seizure rate, social isolation, stress.

---

ATIF KOPYALA