Bosphorus Med J. 2024; 11(3): 97-99 | DOI: 10.14744/bmj.2024.46693

Kronik Hepatit B Akut Alevlenme ve Akut Otoimmün Hepatit Birlikteliði

Hayrettin Sever, Kader Irak
Baþakþehir Cam ve Þakura Þehir Hastanesi, Gastroenteroloji Bölümü, Ýstanbul, Türkiye

Otoimmün hepatit (OH), konakçýnýn baðýþýklýk sisteminin karaciðer parankim hücrelerini hedef aldýðý kronik immünolojik bir karaciðer hastalýðýdýr. Hepatit B virüs (HBV) enfeksiyonunun tetiklemesi ile akut otoimmün hepatit görülebilmektedir. Olgumuzda, kronik zeminde akut hepatit B alevlenmesi ile yatýrýlýp takiplerinde antiviral ve destek tedaviye raðmen klinik ve laboratuvar yanýt alýnamayan bir hastadan otoantikorlar gönderilmiþ ve karaciðer biyopsisi yapýlmýþtýr. Hastaya OH tanýsý konulmuþ ve tedavisine metilprednizolon eklenmiþtir. Bu gibi durumlarda takip sürecinde dikkatli olunmalýdýr.

Anahtar Kelimeler: Akut otoimmün hepatit, kronik hepatit B, karaciðer hastalýðý.

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Acute Exacerbation of Chronic Hepatitis B and Concurrent Acute Autoimmune Hepatitis: A Case Report

Hayrettin Sever, Kader Irak
Department of Gastroenterology, Basaksehir Cam and Sakura City Hospital, Istanbul, Türkiye

Autoimmune hepatitis (AIH) is a chronic immunological liver disease in which the host's immune system targets liver parenchymal cells. Acute autoimmune hepatitis can occur as a result of triggering by hepatitis B virus infection. In our case, autoantibodies were analyzed, and a liver biopsy was performed on a patient hospitalized with acute hepatitis B exacerbation on a chronic background, who showed no clinical or laboratory response despite antiviral and supportive treatment. The patient was diagnosed with AIH, and methylprednisolone was added to the treatment. In such cases, careful follow-up is crucial.

Keywords: Acute autoimmune hepatitis, chronic hepatitis B, liver disease.

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ATIF KOPYALA